IntSide - Statistics

Statistics

Content review
Statistics on Side Effects
Statistics on Biological Features
Statistics on Chemical Features

The contents of IntSide are based on the following databases:

Database	Version
UniprotKB	2015_05
SIDER	2015-08-06
MedDRA	17.1
CTD	2015_08

Database	Version
DrugBank	4.3
STITCH	v4.0
Gene Ontology	1.2_20150910
KEGG	75.1 2015-09-01
ChEBI	131

Content review

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"Features" refers to the number of unique instances considered in the analysis.
"Associated features" is the number of unique instances linked to at least one SE.
"SEs" corresponds to the number of effects in which we found at least an overrepresented feature belonging to the given category.

	Targets	Proteins	Pathways	Processes	Functions	Fragments	Scaffolds	S. terms
Features	931	5503	298	15010	7802	307	3466	4434
Associated features	149	492	259	873	452	117	83	218
SEs	1060	1193	911	799	841	879	653	727

Statistics on Side Effects

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System and Organ Classes

Number of side effects per SOC category

Drugs

Drug side effects cumulative distribution

Associated features

Venn diagrams join SE sets for which associated features were found. 'Proteins' includes 'targets' and 'proteins', and 'GO', 'processes' and 'functions'.

Biology
472

Chemistry
114

963

Proteins
417

Pathways
30

GO
9

775

86

20

98

Fragments
199

Scaffolds
66

Structural terms
90

460

85

42

135

Statistics on Biological Features

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Unique features

Number of unique associated features per biological type

Drugs

Cumulative distribution of drug biological features

Side effects

Cumulative distribution of biological features associated to SEs

Statistics on Chemical Features

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Unique features

Number of unique associated features per chemical type

Drugs

Cumulative distribution of drug biological features

Side effects

Cumulative distribution of chemical features associated to SEs